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Evidence is increasing that most addiction without exception is related to difficulties with the brain's reward center, specially the mesolimbic system. This part of the problem regulates reward responses in acquiring food and sex, as well as in nurturing infants and children. One of the most important neurotransmitters linked to reward responses, both once they malfunction and whenever they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the quantity of dopamine released in in response to a stimulus"(Bostwick & Bucci, 2008).

Using two separate drugs to shed pounds can be very effective there are combinations as you're watching FDA now awaiting approval. When dealing with fat loss and the individuals who go through it you should err along the side of caution and permit the FDA do its job and demand some research be done so the public knows the side effects and dangers of the medications before we bring them. Keep in mind that drug companies come in business to earn money and that they would say everything to keep people on their own medications.

Researchers found that participants using this drug for a year, dropped a few pounds within four weeks and have kept the extra weight off during the entire 56 weeks in the study. Contrave can be a combination with the drugs naltrexone and bupropion, which appears to reflect a brand new trend of weight-loss drugs which might be made up of multiple active ingredient, which might make them more efficient and safer.

Combo-pilling could be the newest fad or also the newest in the future under scrutiny and therefore it is just more publicly known recently, comb-pilling to lose weight has been around since the eighties. The biggest reason that employing a combination of pills is starting to become popular will be the fact that since right now there aren't any long term prescription weight loss supplements that have been licensed by the FDA besides orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications even though some of the combinations are actually rejected or have yet to be authorized by the FDA.

Seizures can be a side effect with Contrave and mustn't be taken in individuals with seizure disorders. The drug also can raise hypertension and heartbeat, and mustn't be used in people with a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise blood pressure and heartrate and must 't be used in patients with uncontrolled high hypertension, as well as by anyone with heart-related and cerebrovascular (circulation dysfunction impacting your brain) disease. Patients with a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes having a boxed warning to alert medical professionals and patients on the increased risk of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stop smoking.


Other people who should avoid using Contrave are patients experiencing bulimia, anorexia nervosa, anyone using opiods, and patients undergoing an 'abrupt discontinuation of alcohol, benzodiazepines, barbiturates and antiepileptic drugs.' Lastly Concave really should not be prescribed for girls who are pregnant or trying to become pregnant.